5.05315

A 438079

• Sinónimos: A 438079, 3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine hydrochloride, P2X7 Purinergic Receptor Antagonist, A 438079, A438079, A-438079
• Fórmula empírica (notación de Hill): C₁₃H₉Cl₂N₅ · xHCl
• Número de CAS: 899507-36-9
• Peso molecular: 306.15 (free base basis)
• UNSPSC Code: 12352200

Propiedades

• assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 100 mM
• storage temp.: 2-8°C
• InChI: 1S/C13H9Cl2N5.ClH/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;/h1-7H,8H2;1H
• InChI key: MBTJFFMIPPMRGR-UHFFFAOYSA-N

Descripción

General description

A potent, competitive, and selective antagonist of P2X₇ purinergic receptor (pIC₅₀ = 6.5 nM and 6.9 nM for rat and human P2X₇ receptor, respectively). Shown to reduce ATP-induced reactive oxygen species formation in MEL cells by about 87% (~10 µM) and blocks BzATP-stimulated changes in intracellular calcium concentrations (IC₅₀ = 100 and 300 nM at rat and human P2X₇ receptors, respectively.

Biochem/physiol Actions

Primary Target
P2X₇

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Donnelly-Roberts, et al., 2007, Br. J. Pharmacol.101, 571.

Wang B, et al., 2013, Purinergic Signal.9, 101.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable