5.04844

7-Chlorokynurenic Acid Sodium Salt

• Sinónimos: 7-Chlorokynurenic Acid Sodium Salt, 7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt
• Fórmula empírica (notación de Hill): C₁₀H₅ClNNaO₃
• Número de CAS: 1263094-00-3
• Peso molecular: 245.59
• MDL number: MFCD12195840
• UNSPSC Code: 12352106
• NACRES: NA.77

Propiedades

• assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• potency: 0.56 μM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: 100 mM
• storage temp.: 2-8°C
• SMILES string: [Na+].Clc1cc2[nH]c(c[c](c2cc1)=O)C(=O)[O-]
• InChI: 1S/C10H6ClNO3.Na/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13;/h1-4H,(H,12,13)(H,14,15);/q;+1/p-1
• InChI key: IFZYIORLNGNLEI-UHFFFAOYSA-M

Descripción

General description

A very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC₅₀ = 0.56 µM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia.

Biochem/physiol Actions

Primary Target
NMDA receptors

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A.85, 6550.
Kretschmer, D., et al. 1995. Eur. J. Pharmacol.280, 37.
Bartlett, D., et al. 1999. Neuropharmacol.37, 839.
Moroni, F., et al. 1991. Eur. J. Pharmacol.199, 32.
Stone, W., et al. 2012. FEBS J.279, 1386.
Vécsei, L., et al. 2012. Nat. Rev. Drug Disc.12, 64.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable