5.00111

Cocarboxylase tetrahydrate

(thiamine pyrophosphate tetrahydrate), EMPROVE^® API

• Sinónimos: Cocarboxylase tetrahydrate
• Fórmula empírica (notación de Hill): C₁₂H₁₈N₄O₇P₂S · 4H₂O
• Número de CAS: 68684-55-9
• Peso molecular: 496.37
• UNSPSC Code: 12352107
• EC Index Number: 205-230-7

Propiedades

• Quality Level: 600
• product line: EMPROVE^® API
• form: solid
• pH: 2.4-3.2 (20 °C, 100 g/L in H₂O)
• solubility: 55 g/L
• bulk density: 450 kg/m³
• application(s): liquid formulation; pharmaceutical; semi-solid formulation; solid formulation
• storage temp.: 2-25°C
• InChI: 1S/C12H18N4O7P2S.4H2O/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;;;;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);4*1H2
• InChI key: KLOLNRGPRQYTIW-UHFFFAOYSA-N

Descripción

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Cocarboxylase tetrahydrate Emprove^® API is a source for Vitamin B1 for use in clinical nutrition, vitamin supplements and infusion for Vitamin B1 deficiency. Cocarboxylase Tetrahydrate (thiamine diphosphoric acid ester tetrahydrate) Emprove^® API is manufactured according to ICH Q7 guidelines. An ASMF is available.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

The substance 5.00111 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable