422689

K_ir2.1 Inhibitor, ML133

The K_ir2.1 Inhibitor, ML133, also referenced under CAS 185669-79-8, controls the biological activity of K_ir2.1. This small molecule/inhibitor is primarily used for Cancer applications.

• Sinónimos: K_ir2.1 Inhibitor, ML133, Inward rectifier potassium channel blocker, ML133
• Fórmula empírica (notación de Hill): C₁₉H₁₉NO
• Número de CAS: 185669-79-8
• Peso molecular: 277.36
• Número MDL: MFCD01469095
• Código UNSPSC: 12352200
• NACRES: NA.28

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 10 mg/mL, clear, colorless
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COC(C=C1)=CC=C1CNCC2=C(C=CC=C3)C3=CC=C2
• InChI: 1S/C19H19NO/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17/h2-12,20H,13-14H2,1H3
• Clave InChI: GIFYKGIODMXYNT-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, K_ir2.1 (IC₅₀ = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the K_ir2.x family, but has no effect on K_ir1.1 (IC₅₀ >300 µM) and displays weak activity for K_ir4.1 and K_ir7.1 (IC₅₀ = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on K_ir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Lindsley, C.W., et al. 2011. ACS Chem. Biol.6, 845.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable