344510

FTase Inhibitor I

The FTase Inhibitor I controls the biological activity of FTase. This small molecule/inhibitor is primarily used for Cancer applications.

• Sinónimos: FTase Inhibitor I, N-[2(S)-[2(R)-Amino-3-mercaptopropylamino]-3-methylbutyl]-Phe-Met-OH, B581
• Fórmula empírica (notación de Hill): C₂₂H₃₈N₄O₃S₂
• Peso molecular: 470.69
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 1 mg/mL; DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

A potent, cell-permeable inhibitor of farnesyltransferase (FTase) that is about 37-fold more active against FTase (IC₅₀ = 21 nM in vitro) than against geranylgeranyltransferase (GGTase; IC₅₀ = 790 nM). Very resistant to proteolysis.

A potent, cell-permeable, selective, peptidomimetic inhibitor of farnesyltransferase (FTase) that is approximately 37-fold more active against FTase (IC₅₀ = 21 nM in vitro) than against geranylgeranyltransferase (GGTase; IC₅₀ = 790 nM). Very resistant to proteolysis.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
FTase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 21 nM against FTase in vitro

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Yamaguchi, M., et al. 2004. Stroke35, 1750.
Cox, A.D., et al. 1994. J. Biol. Chem.269, 19203.
Garcia, A.M., et al. 1993. J. Biol. Chem. 268, 18415.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable