14-781-M

PI3 Kinase (p110α(E545K)/p85α), Murine

• UNSPSC Code: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Propiedades

• recombinant: expressed in baculovirus infected Sf21 cells
• Quality Level: 100; 300
• description: protein target PI3Kα/p85α
• purified by: (Ni²⁺/NTA-agarose)
• technique(s): activity assay: suitable
• UniProt accession no.: P42336
• Gene Information: mouse ... PIK3CA(18706)

Descripción

General description

FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
SIZE: 1068 amino acids; 124284 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.

Packaging

Also available in 250 μg size --call for pricing and availability and reference catalog number 14-781M when ordering the 250 μg size.

Also available in 10 μg size (cat#14-781) and in bulk (cat# 14-781-K).

Physical properties

p110α (Ε545Κ) MW = 129kDa,
p85α MW = 83.6kDa.

Storage and Stability

Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap. Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.

Analysis Note

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable