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07-544

Sigma-Aldrich

Anti-phospho-nNOS/NOS I (Ser1417) Antibody

Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat

packaging

antibody small pack of 25 μg

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

phosphorylation (pSer1417)

Gene Information

human ... NOS1(4842)
rat ... Nos1(24598)

General description

Note: ADMA (Catalog #19-169) and NMMA (Catalog #19-170) are inhibitors of NOS

Specificity

Predicted to cross-react with mouse, zebrafish and frog based on sequence homology.

Immunogen

Peptide corresponding to amino acids surrounding Ser1417 of human neuronal Nitric Oxide Synthase (nNOS).

Application

Anti-phospho-nNOS/NOS I (Ser1417) Antibody is an antibody against phospho-nNOS/NOS I (Ser1417) for use in WB.
Research Category
Neuroscience
Research Sub Category
Oxidative Stress

Quality

Tested

Target description

Mr 170kDa

Physical form

ImmunoAffinity Purified

Other Notes

Please refer to lot specific datasheet.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Leonardo Nogueira et al.
The Journal of physiology, 589(Pt 18), 4615-4631 (2011-07-27)
The flavanol (-)-epicatechin, a component of cacao (cocoa), has been shown to have multiple health benefits in humans. Using 1-year-old male mice, we examined the effects of 15 days of (-)-epicatechin treatment and regular exercise on: (1) exercise performance, (2)
R Socodato et al.
Cell death and differentiation, 21(6), 915-928 (2014-02-18)
During early neurogenesis, retinal neuronal cells display a conserved differentiation program in vertebrates. Previous studies established that nitric oxide (NO) and cGMP accumulation regulate essential events in retinal physiology. Here we used pharmacological and genetic loss-of-function to investigate the effects
David J Kosek et al.
Journal of applied physiology (Bethesda, Md. : 1985), 104(5), 1476-1484 (2008-03-22)
The dystrophin-associated protein complex (DAPC) is a scaffold of proteins linking the intracellular cytoskeleton with the extracellular matrix that is integral to structural stability and integrity, signaling and mechanotransduction, and force transmission. We hypothesized that the expression of DAPC component
Z P Chen et al.
American journal of physiology. Endocrinology and metabolism, 279(5), E1202-E1206 (2000-10-29)
AMP-activated protein kinase (AMPK) is a metabolic stress-sensing protein kinase responsible for coordinating metabolism and energy demand. In rodents, exercise accelerates fatty acid metabolism, enhances glucose uptake, and stimulates nitric oxide (NO) production in skeletal muscle. AMPK phosphorylates and inhibits

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