Focal adhesion kinase family interacting protein of 200 kDa (FIP200) is a novel protein inhibitor for focal adhesion kinase (FAK). FIP200 inhibits kinase activity and associated cellular functions, such as cell adhesion, spreading, and motility in fibroblasts by binding directly to FAK.
Especificidad
This antibody recognizes the C-terminal region of FIP200.
Inmunógeno
Epitope: C-terminus
The immunogen was a synthetic peptide corresponding to the C-terminal region of FIP200.
Aplicación
Detect FIP200 using this Anti-FIP200 Antibody validated for use in WB.
Research Category Signaling
Research Sub Category PI3K, Akt, & mTOR Signaling
Calidad
Evaluated by western blot on HEK293 cell lysate. Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect FIP200 in HEK293 cell lysate.
Descripción de destino
200 kDa
Forma física
Unpurified rabbit serum in buffer containing 0.05% sodium azide.
Almacenamiento y estabilidad
Stable for 2 years at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
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The Journal of clinical investigation, 130(9), 5011-5026 (2020-08-18)
Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the underlying mechanism and its pathogenic role remain elusive. We show that autophagy was inhibited in DKD models and in human diabetic kidneys. Ablation of autophagy-related gene 7
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