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T-904

Supelco

Trimipramine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C20H26N2
Número de CAS:
739-71-9
Peso molecular:
294.43
Número MDL:
MFCD00242595
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329826892
NACRES:
NA.24

grado

certified reference material

Formulario

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

envase

ampule of 1 mL

fabricante / nombre comercial

Cerilliant®

concentración

1.0 mg/mL in methanol

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

clinical testing

Formato

single component solution

temp. de almacenamiento

2-8°C

cadena SMILES

CN(C)CC(C)CN1C2=C(C=CC=C2)CCC3=C1C=CC=C3

InChI

1S/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3

Clave InChI

ZSCDBOWYZJWBIY-UHFFFAOYSA-N

Información sobre el gen

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , DRD2(1813) , HRH1(3269) , HTR2A(3356) , HTR2C(3358) , SLC6A2(6530)

Descripción general

Trimipramine is a tricyclic antidepressant prescribed for treatment of depression, insomnia, and chronic pain or as an adjunctive therapy for alcohol or opioid withdrawal. This certified solution standard is applicable for use in clinical toxicology, forensic analysis, or urine drug testing applications by LC-MS/MS or GC/MS. Trimipramine is marketed under the trade names Surmontil®, Rhotrimine, and Stangyl.

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Surmontil is a registered trademark of Pliva, Inc.

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órganos de actuación

Eyes,Central nervous system

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

49.5 °F - closed cup

Punto de inflamabilidad (°C)

9.7 °C - closed cup

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Britta Haenisch et al.
Psychopharmacology, 217(2), 289-295 (2011-04-13)
The antidepressant trimipramine shows an atypical pharmacological profile and its mechanism of action is still obscure. The present study investigated whether trimipramine and three of its metabolites interact with targets of other antidepressants, namely, the human monoamine transporters for noradrenaline
M T Jafari et al.
Analytical and bioanalytical chemistry, 399(10), 3555-3564 (2011-02-08)
A novel method based on three-phase hollow fiber microextraction technique (HF-LPME) coupled with electrospray ionization-ion mobility spectrometry (ESI-IMS) was developed for the simultaneous determination of two antidepressant drugs (trimipramine and desipramine) in urine and plasma samples. The effects of various
Michael Schredl et al.
Psychiatry research, 167(3), 279-286 (2009-05-01)
Trimipramine is a sedating tricyclic antidepressant which is not only effective in the treatment of depression but also in primary insomnia. In contrast to most other antidepressants, trimipramine does not affect rapid eye movement sleep. In a large sample of
Yusuf Oztürk et al.
Pharmacology, biochemistry, and behavior, 83(4), 592-597 (2006-05-23)
The present study was designed to investigate the involvement of endogenous opioid systems in the antinociception induced by the antidepressant drugs, desipramine and trimipramine. For this purpose, the antinociceptive effects of desipramine (7.5 and 15.0 mg/kg i.p.) and trimipramine (5.0
Diansong Zhou et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(5), 863-870 (2010-02-06)
The role of human UDP glucuronosyltransferase (UGT) 2B10 in the N-glucuronidation of a number of tricyclic antidepressants was investigated and compared with that of UGT1A4 in both the Sf9 expressed system and human liver microsomes. The apparent K(m) (S(50)) values
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