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999994P

Avanti

12:0 Diether PC

Avanti Research™ - A Croda Brand 999994P, powder

Sinónimos:

1,2-di-0-dodecyl-sn-glycero-3-phosphocholine

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About This Item

Fórmula empírica (notación de Hill):
C32H68NO6P
Número de CAS:
72593-72-7
Peso molecular:
593.86
UNSPSC Code:
51191904
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 10 mg (999994P-10mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 999994P

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OCCCCCCCCCCCC)COCCCCCCCCCCCC)=O

Categorías relacionadas

General description

12:0 Diether PC (phosphocholine) is a glycerophospholipid having choline as the alcohol moiety, attached to the phosphate group. It has two dodecane chains attached to the sn-1 and sn-2 positions of the glycerol backbone by ether bonds.

Application

12:0 Diether PC or 1,2-di-O-dodecyl-sn-glycero-3-phosphocholine might be used in small micelles to study the interaction of peptides with model membranes by nuclear magnetic resonance (NMR) experiments.

Biochem/physiol Actions

12:0 Diether PC (phosphocholine) is useful in bicelles formation. Bicelles are suitable to be integrated into standard crystallization protocols and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. It is found to be a simpler membrane model and is highly compatible with nuclear magnetic resonance (NMR).

Packaging

5 mL Amber Glass Screw Cap Vial (999994P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Interaction of a peptide derived from C-terminus of human TRPA1 channel with model membranes mimicking the inner leaflet of the plasma membrane
Witschas K, et al.
Biochimica et Biophysica Acta - Biomembranes, 1848(5), 1147-1156 (2015)
Structural and functional roles of ether lipids
Dean JM and Lodhi IJ
Protein & cell, 9(2), 196-206 (2018)

Artículos

Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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