857131C

14:0 BMP (S,R)

bis(monomyristoylglycero)phosphate (S,R Isomer) (ammonium salt), chloroform

• Sinónimos: sn-(3-tetradecanoyl-2-hydroxy)-glycerol-1-phospho-sn-3′-(1′-tetradecanoyl-2′-hydroxy)-glycerol (ammonium salt); lysobisphosphatidic acid; LBPA; 110857
• Fórmula empírica (notación de Hill): C₃₄H₇₀NO₁₀P
• Número de CAS: 325466-03-3
• Peso molecular: 683.89
• UNSPSC Code: 12352211

Propiedades

• assay: >99% (BMP (contains 30% positional isomers), TLC)
• form: liquid
• packaging: pkg of 1 × 1 mL (857131C-10mg); pkg of 1 × 1 mL (857131C-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 857131C
• concentration: 10 mg/mL (857131C-10mg); 5 mg/mL (857131C-5mg)
• lipid type: cardiolipins; phospholipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@@](COP(OC[C@@]([H])(O)COC(CCCCCCCCCCCCC)=O)([O-])=O)(O)COC(CCCCCCCCCCCCC)=O.[NH4+]

Descripción

General description

Bis(monoacylglycerol) phosphate (BMP) is a phospholipid, containing two-phosphate linked fatty acid esterified glycerol molecule. It is present in late endosome, mainly in intraluminal vesicles (ILVs).[1] BMP accounts to 15% of total organelle lipids.[2]

Application

14:0 BMP (S,R) is suitable to use as the internal standard for lipid extractions and mass spectrometric quantification from Detergent-resistant membrane (DRM) and detergent-soluble membrane (DSM) fractions.[3][4]

Biochem/physiol Actions

Bis(monoacylglycerol)phosphate (BMP) plays a key role in cargo sorting[1] and protein and lipid trafficking.[2] The levels of BMP is elevated in lysosomal storage disorders (LSD) including Wolman disease, Niemann Pick disease and neuronal ceroid lipofuscinoses.[1] It is resistant to degradation by the enzyme, acid phospholipase.[5]

Packaging

5 mL Clear Glass Sealed Ampule (857131C-10mg)

5 mL Clear Glass Sealed Ampule (857131C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H302,H315,H319,H331,H336,H351,H361d,H372
• pcodes: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• target_organs: Liver,Kidney, Respiratory system
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: does not flash
• flash_point_c: does not flash