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810219P

Avanti

C12-NBD Sphingomyelin

Avanti Research™ - A Croda Brand 810219P, powder

Sinónimos:

N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sphingosine-1-phosphocholine

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1 MG
MXP 11,617.00

MXP 11,617.00

Fecha estimada de envío17 de abril de 2025

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1 MG
MXP 11,617.00

About This Item

Fórmula empírica (notación de Hill):
C41H73N6O9P
Número de CAS:
254117-01-6
Peso molecular:
825.03
MDL number:
MFCD02259246
UNSPSC Code:
12352211
NACRES:
NA.25

MXP 11,617.00

Fecha estimada de envío17 de abril de 2025

Solicitar un pedido a granel

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (810219P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810219P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[P](=O)([O-])(OC[C@H](NC(=O)CCCCCCCCCCCNc1c2n[o]nc2c(cc1)[N+](=O)[O-])[C@H](O)\C=C\CCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C41H73N6O9P/c1-5-6-7-8-9-10-11-12-13-15-18-21-24-27-38(48)36(34-55-57(52,53)54-33-32-47(2,3)4)43-39(49)28-25-22-19-16-14-17-20-23-26-31-42-35-29-30-37(46(50)51)41-40(35)44-56-45-41/h24,27,29-30,36,38,48H,5-23,25-26,28,31-34H2,1-4H3,(H2-,42,43,45,49,52,

InChI key

FCQMKLRMKNYONQ-YPGNEAGUSA-N

Categorías relacionadas

General description

C12-NBD Sphingomyelin is a fluorescent analog of biologically active molecule, sphingomyelin.[1] Sphingomyelin is predominantly found in the animal plasma membrane. It is abundantly present as component of cell membranes in mammals, nematodes, protozoa.[2]

Application

C12-NBD-sphingomyelin has been used as a substrate to test substrate specificity of neutral ceramidase orthologue encoded by AsahA gene.[3]

Biochem/physiol Actions

Sphingomyelin (SM) is produced from phosphatidylcholine and ceramide on the cell surface and in lumen of the Golgi. SM′s high packing density and affinity to sterols form a rigid barrier to the extracellular environment. SM is also involved in the formation of lipid rafts in cell membranes, which perform important functions in signal transduction and membrane trafficking.[2]

Packaging

5 mL Amber Glass Screw Cap Vial (810219P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Characterization of a neutral ceramidase orthologue from Aspergillus oryzae
Tada S, et al.
FEMS Microbiology Letters, 298(2), 157-165 (2009)
Sawaki Tada et al.
FEMS microbiology letters, 298(2), 157-165 (2009-08-05)
Ceramide is an important molecule not only structurally but also regulationally as a modulator of various cellular events. Ceramidase (CDase) are classified into three different types (acid, alkaline, and neutral CDases). Neutral CDase could play an important role in the
Fluorescent and Luminescent Probes for Biological Activity (1999)
Hyun-Seok Lee et al.
International journal of molecular sciences, 21(3) (2020-02-08)
Human epidermis is positioned at the interface with the external environment, protecting our bodies against external challenges, including air pollutants. Emerging evidence suggests that diesel particulate extract (DPE), a major component of air pollution, leads to impairment of diverse cellular
Klazien Huitema et al.
The EMBO journal, 23(1), 33-44 (2003-12-20)
Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, yielding diacylglycerol as a side product. This reaction is catalysed by SM synthase, an enzyme whose biological potential can

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