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810192P

Avanti

16:0-06:0 NBD PS

Avanti Research™ - A Croda Brand 810192P, powder

Sinónimos:

1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoserine (ammonium salt)

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1 MG
MXP 11,811.00

MXP 11,811.00

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1 MG
MXP 11,811.00

About This Item

Fórmula empírica (notación de Hill):
C34H59N6O13P
Número de CAS:
384833-06-1
Peso molecular:
790.84
Número MDL:
MFCD02066201
Código UNSPSC:
12352211
NACRES:
NA.25

MXP 11,811.00

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Ensayo

>99% (TLC)

Formulario

powder

envase

pkg of 1 × 1 mg (810192P-1mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand 810192P

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

Descripción general

Phosphatidylserine (PS) is a membrane phospholipid enriched in the cytosolic leaflet of plasma membrane. It comprises 2-10% of total phospholipids.[1] NBD PS is a flurosently labelled phospholipid with 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at the headgroup of PS.[2]

Aplicación

16:0-06:0 NBD PS has been used as a labelled translocase to detect ATP-dependent translocation across late Golgi membranes.[3] It is also suitable for analysis of phospholipid scramblase 1 (PLSCR1) scrambling in proteoliposomes[4] and to determine enzyme specificity of lipoteichoic acid synthase enzyme (LtaS).[5]
16:0-06:0 NBD PS or 1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoserine (ammonium salt) has been used in the 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) − phospholipase (PL) translocation assay to characterize an ATP-dependent flippase activity in yeast Golgi membranes.[6] It may be used: to detect vesicular stomatitis virus G (VSV G) protein mediated cell-cell fusion[7], measure the enzyme substrate specificity of lipoteichoic acid (LTA) synthase (LtaS)[8], in liposomes to determine the role of phospholipid scramblase 1 (PLSCR1) in phospholipid scrambling.[9]

Acciones bioquímicas o fisiológicas

Phosphatidylserine (PS) is involved in the regulation of many enzymes and structural components.[10] It serves as an essential factor in the clearance of apoptotic cells.[10] It is associated with cognitive disability in Alzheimer′s disease.[11]

Envase

5 mL Amber Glass Screw Cap Vial (810192P-1mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de clase de almacenamiento

11 - Combustible Solids

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An Unrecognized Function of Cholesterol: Regulating the Mechanism Controlling Membrane Phospholipid Asymmetry
Arashiki N, et al.
Biochemistry, 55(25), 3504-3504 (2016)
Elena Zaitseva et al.
Cell host & microbe, 22(1), 99-110 (2017-07-14)
HIV-1 entry into host cells starts with interactions between the viral envelope glycoprotein (Env) and cellular CD4 receptors and coreceptors. Previous work has suggested that efficient HIV entry also depends on intracellular signaling, but this remains controversial. Here we report
Paramasivam Natarajan et al.
Methods (San Diego, Calif.), 39(2), 163-168 (2006-07-11)
Phospholipid asymmetry is a fundamental feature of the plasma membrane of most eukaryotic cells and its regulation is linked to diverse physiological processes such as apoptosis and blood clotting [P. Williamson, R.A. Schlegel, Biochim. Biophys. Acta 1585 (2002) 53-63; R.F.
Osmotic stress adaptation in Lactobacillus casei BL23 leads tostructural changes in the cell wall polymer lipoteichoic acid
Palomino MM, et al.
Microbiology, 159(11), 2416-2426 (2013)
Measuring translocation of fluorescent lipid derivatives across yeast Golgi membranes
Natarajan P, et al.
Methods, 39(2), 163-168 (2006)
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