Saltar al contenido
Merck
Todas las fotos(2)

Documentos

810189P

Avanti

TopFluor™ PI(3,4,5)P3

Avanti Research™ - A Croda Brand 810189P, powder

Sinónimos:

1-oleoyl-2-{12-[4-(dipyrrometheneboron difluoride)butanoyl]amino}dodecanoyl-sn-glycero-3-phosphoinositol-3,4,5-trisphosphate (ammonium salt)

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(2)

About This Item

Fórmula empírica (notación de Hill):
C56H108 BF2 N7O23P4
Número de CAS:
2260795-37-5
Peso molecular:
1420.19
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 50 μg (with stopper and crimp cap (810189P-50ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand 810189P

shipped in

dry ice

storage temp.

−20°C

General description

PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) is restricted to the cell membrane of inner leaflet. TopFluor™ PI(3,4,5)P3 is a fluorescently labeled-phosphoinositide derivative containing saturated acyl chain.
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) is an inadequate phospholipid present on the inner leaflet of the plasma membrane.

Biochem/physiol Actions

PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) serves as a substrate for PTEN (phosphatase and tensin homolog), a tumor suppressor protein. It has binding affinity towards the active site of phosphatase domain. TopFluor™ PI(3,4,5)P3 might be useful in monitoring protein induced phosphoinositide clustering. This product is considered photostable than other fluorophores.
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) plays a key role in inducing the cluster of Syntaxin1A at presynaptic terminals. It also regulates the activity protein kinase B/Akt.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (810189P-50ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Biophysical methods for the characterization of PTEN/lipid bilayer interactions
Harishchandra RK, et al.
Methods, 125-125 (2015)
Synaptic PI(3,4,5)P3 Is Required for Syntaxin1A Clustering and Neurotransmitter Release
Khuong TM, et al.
Neuron, 77(6), 1097-1108 (2013)
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
Ebner M, et al.
Molecular Cell, 65(3), 416-431 (2017)
Biophysical methods for the characterization of PTEN/lipid bilayer interactions
Harishchandra RK, et al.
Methods, 77, 125-135 (2015)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico