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Merck
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Documentos

700087P

Avanti

DHEA

Avanti Research™ - A Croda Brand

Sinónimos:

DHEA; 3β-hydroxy-5-androsten-17-one; 5-androsten-3β-ol-17-one; dehydroisoandrosterone; trans-dehydroandrosterone; Prasterone

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About This Item

Fórmula empírica (notación de Hill):
C19H28O2
Número de CAS:
53-43-0
Peso molecular:
288.42
UNSPSC Code:
12352211
NACRES:
NA.25

description

Dehydroepiandrosterone

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (700087P-1g)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1

InChI key

FMGSKLZLMKYGDP-USOAJAOKSA-N

General description

25-hydroxy-cholesterol is a metabolite of cholesterol. It is produced by macrophages.
DHEA (dehydroepiandrosterone) is an endogenous steroid hormone secreted by the adrenal gland. DHEA serves as precursor to male and female sex hormones (androgens and estrogens).
Dehydroepiandrosterone (DHEA) is a carbon (C)-19 neuroactive steroid. It is synthesized by the adrenal gland in humans and mammals.

Biochem/physiol Actions

25-hydroxy-cholesterol represses the production of IgA by B cells, manages the migration of activated B cells in the germinal follicle. It regulates the differentiation of monocytes into macrophages. 25-hydroxy-cholesterol plays a critical role in lipid biosynthesis and immunity. It inhibits sterol regulatory element-binding protein (SREBP) proteolytic processing and modulates cholesterol metabolism.
Dehydroepiandrosterone (DHEA) regulates neural functions, such as neurogenesis, neuroprotection, neuronal growth and differentiation. It is used to treat multiple sclerosis. DHEA acts as a precursor of sex steroid biosynthesis.

Packaging

20 mL Clear Glass Screw Cap Vial (700087P-1g)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Referencia del producto
Descripción
Precios

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361fd

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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17α-Hydroxypregnenolone

Sigma-Aldrich

H5002

17α-Hydroxypregnenolone

Oxythiamine chloride hydrochloride ≥95% (HPLC)

Sigma-Aldrich

O4000

Oxythiamine chloride hydrochloride

25-Hydroxycholesterol: a new life in immunology
McDonald JG and Russell DW
Journal of Leukocyte Biology, 88(6), 1071-1072 (2010)
25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages
Shibata N, et al.
The Journal of biological chemistry, 288(50), 35812-35823 (2013)
Sex Hormones in Neurodegenerative Processes and Diseases (2018)
Kuei-Fang Chung et al.
Molecular and cellular endocrinology, 336(1-2), 141-148 (2010-12-07)
Dehydroepiandrosterone producing adrenocortical zona reticularis and the adrenal medulla are in direct contact and are highly intermingled in many species. This results in potentially strong paracrine influences of high local dehydroepiandrosterone concentrations on the adrenal medulla. Dehydroepiandrosterone has neuroprotective properties
P Ebeling et al.
Lancet (London, England), 343(8911), 1479-1481 (1994-06-11)
Dehydroepiandrosterone (DHEA), with its sulphate conjugate (DHEAS), is the most abundant steroid hormone in the circulation but its physiological importance is unclear. We propose that DHEA has either oestrogen-like or androgen-like effects depending on the hormonal milieu. In premenopausal women
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