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700040P

Avanti

desmosterol-d6

Avanti Research™ - A Croda Brand

Sinónimos:

24-dehydrocholesterol(d6); 5,24-cholestadien-3β-ol(d6)

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About This Item

Fórmula empírica (notación de Hill):
C27H38OD6
Número de CAS:
1246298-67-8
Peso molecular:
390.67
Número MDL:
MFCD00010474
Código UNSPSC:
12352100
NACRES:
NA.25
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descripción

cholesta-5,24-dien-3β-ol-d6

Ensayo

>99% (TLC)

Formulario

powder

envase

pkg of 1 × 1 mg (700040P-1mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

Descripción general

Desmosterol constitutes 1% of brain sterol and is catabolized to cholesterol by the enzyme 3-hydroxysterol 24-reductase (DHCR24).[1] It is an intermediate in the Bloch branch of the cholesterol biosynthesis pathway.[2] Desmosterol-d6 is a deuterated form of desmosterol.

Aplicación

Desmosterol-d6 has been used:
  • as a deuterated standard in liquid chromatography multiple reaction monitoring (LC-MRM)[3]
  • as a deuterated standard in high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)[4]
  • for spiking brain tissue homogenate from Alzheimer′s disease (AD) for liquid chromatography -mass spectrometry (LC-MS) analysis[5]

Acciones bioquímicas o fisiológicas

Desmosterol low levels in the hippocampus directly impacts progenitor cell differentiation into neurons.[1] Desmosterol-d6 is used as a substitute to desmosterol in hepatitis C virus (HCV) based viral assays to rescue replication.[2] Desmosterol being a C27 sterol intermediate is implicated in the Alzheimer′s disease (AD) pathogenesis.[5]

Envase

5 mL Amber Glass Screw Cap Vial (700040P-1mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

11 - Combustible Solids

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Valerie A Villareal et al.
ACS chemical biology, 11(7), 1827-1833 (2016-04-30)
Hepatitis C virus (HCV) increases intracellular desmosterol without affecting the steady-state abundance of other sterols, and the antiviral activity of inhibitors of desmosterol synthesis is suppressed by the addition of exogenous desmosterol. These observations suggest a model in which desmosterol
Yoshiaki Sato et al.
Alzheimer's & dementia (Amsterdam, Netherlands), 1(1), 67-74 (2015-03-01)
We here examined whether plasma desmosterol-to-cholesterol ratio (DES/CHO) is decreased in patients with Alzheimer's disease (AD) and investigated the association between plasma DES/CHO and longitudinal cognitive decline. Plasma DES/CHO of AD patients and age-matched controls in a Japanese cross-sectional cohort
Thomas Wisniewski et al.
Journal of Alzheimer's disease : JAD, 33(3), 881-888 (2012-10-09)
Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It has become of particular interest in the pathogenesis of Alzheimer's disease (AD) because of the report that the activity of
Jeffrey G McDonald et al.
Methods in enzymology, 432, 145-170 (2007-10-24)
We describe the development of a high performance liquid chromatography mass spectrometry (HPLC-MS) method that allows the identification and quantitation of sterols in mammalian cells and tissues. Bulk lipids are extracted from biological samples by a modified Bligh/Dyer procedure in
Priyadarshini Chakrabarti et al.
Metabolomics : Official journal of the Metabolomic Society, 15(10), 127-127 (2019-09-21)
Significant annual honey bee colony losses have been reported in the USA and across the world over the past years. Malnutrition is one among several causative factors for such declines. Optimal nutrition serves as the first line of defense against

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