m-dPEG48-MAL is a thiol-reactive, monodispersed PEGylation reagent used for surface and biomolecule modification. One end of the PEG molecule is methyl-terminated. The opposite end possesses a 3-maleimido propanoic acid functional group that connects to the PEG spacer via an amide bond. The maleimide moiety reacts with sulfhydryl groups by the thiol-Michael addition reaction. The single molecular weight, discrete-length PEG (dPEG) chain is 152 atoms (178.6 Å) long, including the reactive site on the maleimide ring. The dPEG48 is a monodisperse equivalent of the polymeric PEG2000.
Legal Information
Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Self-assembling protein nanocapsules can be engineered for various bionanotechnology applications. Using the dodecahedral scaffold of the E2 subunit from pyruvate dehydrogenase, we introduced non-native surface cysteines for site-directed functionalization. The modified nanoparticle's structural, assembly, and thermostability properties were comparable to
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