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This product has not been tested for solubility or suitability in cell culture. The solubility is tested in Chloroform at 50 mg/ml. However, various sources report that this compound is also slightly soluble in DMSO and Ethanol. This information has not been validated. The end-user would have to determine suitability for cell culture applications.
N3633
β-Naphthoflavone
≥98%
Sinónimos:
beta-Naphthoflavone, 5,6-Benzoflavone, BNF
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1 G
MXP 1,465.00
5 G
MXP 4,490.00
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1 G
MXP 1,465.00
5 G
MXP 4,490.00
About This Item
Fórmula empírica (notación de Hill):
C19H12O2
Número de CAS:
Peso molecular:
272.30
Beilstein:
18991
Número CE:
Número MDL:
Código UNSPSC:
12352100
ID de la sustancia en PubChem:
NACRES:
NA.22
Productos recomendados
Ensayo
≥98%
color
off-white to yellow
mp
164-166 °C (lit.)
temp. de almacenamiento
2-8°C
cadena SMILES
O=C1C=C(Oc2ccc3ccccc3c12)c4ccccc4
InChI
1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H
Clave InChI
OUGIDAPQYNCXRA-UHFFFAOYSA-N
Información sobre el gen
rat ... Gabra2(29706)
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Descripción general
β-Naphthoflavone is a polyaromatic hydrocarbon.[1]
Aplicación
β-Naphthoflavone has been used:
- as aryl hydrocarbon receptor agonist to elucidate its effect on Cyp1A1 expression in embryos of transgenic cytochrome P450 1A1 (cyp1a) reporter zebrafish[2]
- as AhR agonists, to treat primary normal human epidermal keratinocytes (NHEKs) to study about aryl hydrocarbon receptor (AhR) activation by western blot analysis[3]
- to determine its effect on the expression of dystrophin (Dp)71[1]
- to stimulate the expression of causes recombination (Cre) recombinase and to delete the flanking alleles of locus of crossing (x) over, P1 (loxP) sequences[4]
Acciones bioquímicas o fisiológicas
β-Naphthoflavone (BNF) is an exogenous ligand for aryl hydrocarbon receptor (AhR) in humans.[2] It is an inducer of phase I detoxification enzymes (CYPs) and phase II enzymes (UDP-GTs) and NAD(P)H-dependent quinone oxyreductase-1(NQO1). It also induces cytochrome P450 (Cyp1a).[5] BNF represses the expression of Duchenne muscular dystrophy gene, dystrophin (Dp)71 by altering the binding of the transcription factors.[1]
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Artículos
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
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How can I reconstitute the reagent β-Naphthoflavone (Ref# N3633-1G) for cell culture? Is it soluble in ethanol or DMSO?
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