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M74253

Sigma-Aldrich

N-Methyl-N-propargylbenzylamine

97%

Sinónimos:

Pargyline

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About This Item

Fórmula lineal:
C6H5CH2N(CH3)CH2C≡CH
Número de CAS:
555-57-7
Peso molecular:
159.23
EC Number:
209-101-6
MDL number:
MFCD00008576
UNSPSC Code:
12352100
PubChem Substance ID:
24897164
NACRES:
NA.22

assay

97%

form

liquid

refractive index

n20/D 1.522 (lit.)

bp

86-88 °C/4 mmHg (lit.)

density

0.944 g/mL at 25 °C (lit.)

SMILES string

CN(CC#C)Cc1ccccc1

InChI

1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3

InChI key

DPWPWRLQFGFJFI-UHFFFAOYSA-N

Gene Information

human ... MAOA(4128) , MAOB(4129)

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

183.2 °F - closed cup

flash_point_c

84 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Sergiy Konovalov et al.
Journal of ovarian research, 6(1), 75-75 (2013-10-30)
Lysine-specific demethylase 1 (LSD1, also known as KDM1A and AOF2) is a chromatin-modifying activity that catalyzes the removal of methyl groups from lysine residues in histone and non-histone proteins, regulating gene transcription. LSD1 is overexpressed in several cancer types, and
Masahiro Yoshida et al.
The Journal of organic chemistry, 78(4), 1687-1692 (2013-02-01)
The reaction of propargylic carbonates with 4-hydroxy-2-pyrones in the presence of a palladium catalyst is described. By the choice of the reaction temperature, two types of the substituted furo[3,2-c]pyran-4-one derivatives were regioselectively synthesized, respectively.
Shauna N Vasilatos et al.
Carcinogenesis, 34(6), 1196-1207 (2013-01-29)
Our previous studies demonstrated that lysine-specific demethylase 1 (LSD1) and histone deacetylases (HDACs) closely interact in controlling growth of breast cancer cells. However, the underlying mechanisms are largely unknown. In this study, we showed that knockdown of LSD1 expression (LSD1-KD)
Gangadhara R Sareddy et al.
Oncotarget, 4(1), 18-28 (2012-12-19)
Glioma development is a multistep process, involving alterations in genetic and epigenetic mechanisms. Understanding the mechanisms and enzymes that promote epigenetic changes in gliomas are urgently needed to identify novel therapeutic targets. We examined the role of histone demethylase KDM1
Avanashiappan Nandakumar et al.
Organic letters, 15(2), 382-385 (2013-01-12)
Tetrasubstituted olefin based new xanthene derivatives have been synthesized via palladium-catalyzed carbopalladation/C-H activation of 2-bromobenzyl-N-propargylamine derivatives. The synthesized compounds display a pronounced solid state fluorescence due to their restricted internal rotation of a C-Ar bond in the solid or aggregation
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