The AgNO3 titration is used to determine the HCl content in the molecule, and the mentioned 12.9% is indeed the HCl content.
915572
Pomalidomide-dipiperazine-NH2 hydrochloride
≥95%
Sinónimos:
4-(4-(4-(2-Aminoethyl)piperazine-1-carbonyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride, Crosslinker−E3 ligase ligand conjugate, Pomalidomide conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader
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50 MG
MXP 9,654.00
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50 MG
MXP 9,654.00
About This Item
Fórmula empírica (notación de Hill):
C24H31N7O5 · xHCl
Peso molecular:
497.55 (free base basis)
Código UNSPSC:
12352101
NACRES:
NA.22
Productos recomendados
ligand
pomalidomide
Nivel de calidad
Ensayo
≥95%
Formulario
powder
idoneidad de la reacción
reactivity: carboxyl reactive
reagent type: ligand-linker conjugate
grupo funcional
amine
temp. de almacenamiento
2-8°C
cadena SMILES
O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC=C3N4CCN(C(N5CCN(CCN)CC5)=O)CC4
Clave InChI
KLJJLERZEMIGTG-UHFFFAOYSA-N
Categorías relacionadas
Aplicación
Protein degrader building block Pomalidomide-dipiperazine-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a rigid linker, and a pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Otras notas
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Targeted Protein Degradation by Small Molecules
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Targeted Protein Degradation by Small Molecules
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Información legal
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Producto relacionado
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Artículos
Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.
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Can the mentioned number (12.9%) be considered as the percentage of HCl, given that the amount of HCl in general is typically determined by titration? Additionally, the only test listed is "Titration with AgNO3," but it does not specify what is being titrated.
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