765341
Gold nanoparticles
20 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O
Sinónimos:
Gold nanoparticles NH2 functionalized, Au NP NH2, Gold Colloid
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1 ML
MXP 10,549.00
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1 ML
MXP 10,549.00
About This Item
Código UNSPSC:
12162002
NACRES:
NA.23
Productos recomendados
Materiales
PEG 5000
Nivel de calidad
Formulario
dispersion in H2O
nanoparticles
envase
poly bottle of 1 mL
DO
50
diámetro
20 nm
pH
6.0-8.0 (25 °C)
solubilidad
water: miscible
densidad
1.00 g/cm3
λmáx.
520 nm
grupo funcional
amine
temp. de almacenamiento
2-8°C
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Descripción general
Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which have Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.[1][2][3][4]
Aplicación
Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Several other specific applications have been listed below:
- Since they adhere to cell membranes, AuNPs are used in cellular and intracellular targeting in targeted drug delivery applications and may also be used in biodistribution studies
- AuNPs may also be used in photothermal therapy and radiotherapy.
- Proposed applications of gold nanoparticles are as:drug delivery agents for cancer therapy, coatings, plastics, nanowire, nanofiber, textiles, catalyst applications.
- They may also be used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.[5][4]
Características y beneficios
- The negatively charged siRNA-PEG complex, attached to positively charged GNPs, is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.[5][4]
- The PEG coating decreases the cytotoxicity and increases effciciency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.[1]
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Artículos
The recent emergence of a number of highly functional nanomaterials has enabled new approaches to the understanding, diagnosis, and treatment of cancer.
Biomaterials science integrates smart materials into biological research, requiring a deep understanding of biological systems.
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