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Documentos

57865

Sigma-Aldrich

4-Nitrophenyl iodoacetate

≥99.0%

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About This Item

Fórmula empírica (notación de Hill):
C8H6INO4
Número de CAS:
31252-85-4
Peso molecular:
307.04
Beilstein/REAXYS Number:
1970746
EC Number:
250-536-6
MDL number:
MFCD00042813
UNSPSC Code:
12352100
PubChem Substance ID:
57651634
NACRES:
NA.22

assay

≥99.0%

mp

79-82 °C

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(OC(=O)CI)cc1

InChI

1S/C8H6INO4/c9-5-8(11)14-7-3-1-6(2-4-7)10(12)13/h1-4H,5H2

InChI key

GERXSZLDSOPHJV-UHFFFAOYSA-N

Other Notes

For introducing the iodoacetyl group in peptides; Synthesis of N-methyl iodoacetamide

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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K Sutoh et al.
Biochemistry, 27(8), 2964-2969 (1988-04-19)
Subfragment 1 (S1) prepared from rabbit skeletal muscle myosin was digested with trypsin to cleave the 95K heavy chain into three pieces, i.e., the 23K, 50K, and 20K fragments. The trypsin-treated S1 was then cross-linked with p-nitrophenyl iodoacetate. The cross-linker
T Hiratsuka
Biochemistry, 26(11), 3168-3173 (1987-06-02)
When myosin subfragment 1 (S-1) reacts with the bifunctional reagents with cross-linking spans of 3-4.5 A, p-nitrophenyl iodoacetate and p-nitrophenyl bromoacetate, the 20-kilodalton (20-kDa) segment of the heavy chain is cross-linked to the 26-kDa segment via the reactive thiol SH2.
U Ramseier et al.
Analytical biochemistry, 221(2), 231-233 (1994-09-01)
Cysteine residues derivatized with N-methyl iodoacetamide (MIAA) can be analyzed by the Edman sequencing with a high degree of reliability. By HPLC, the phenylthiohydantoin (PTH) derivative of MIAA-modified cysteine eluted between dimethylphenylthiourea and PTH-Ala--a wide gap which is not occupied
Ya Zhang et al.
International journal of nanomedicine, 7, 1015-1022 (2012-03-10)
Polymersomes are nanosized vesicles formed from amphiphilic block copolymers, and have been identified as potential drug delivery vehicles to the inner ear. The aim of this study was to provide targeting to specific cells within the inner ear by functionalizing
Synthesis and characterization of two fluorescent sulfhydryl reagents.
E N Hudson et al.
Biochemistry, 12(21), 4154-4161 (1973-10-09)

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