430676

2,2,5,7,8-Pentamethyl-6-chromanol

97%

• Sinónimos: α-C-1-Chromanol, 2,2,5,7,8-Pentamethyl-3,4-dihydrochromen-6-ol, 2,2,5,7,8-Pentamethyl-6-hydroxychroman, 3,4-Dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-ol, 6-Hydroxy-2,2,5,7,8-pentamethylchroman
• Fórmula empírica (notación de Hill): C₁₄H₂₀O₂
• Número de CAS: 950-99-2
• Peso molecular: 220.31
• Número MDL: MFCD00210347
• Código UNSPSC: 12352100
• ID de la sustancia en PubChem: 24866935
• NACRES: NA.22

Propiedades

• Ensayo: 97%
• Formulario: solid
• mp: 89-91 °C (lit.)
• cadena SMILES: Cc1c(C)c2OC(C)(C)CCc2c(C)c1O
• InChI: 1S/C14H20O2/c1-8-9(2)13-11(10(3)12(8)15)6-7-14(4,5)16-13/h15H,6-7H2,1-5H3
• Clave InChI: SEBPXHSZHLFWRL-UHFFFAOYSA-N
• Información sobre el gen: human ... AR(367)

Descripción

Descripción general

2,2,5,7,8-Pentamethyl-6-chromanol has been reported as an vitamin E model compound.[1] It undergoes oxidation in presence of various alcohols, ranging from methanol to cholesterol, affords 5-alkoxymethyl-2,2,7,8-tetramethyl-6-chromanols.[2] Antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol (PMCol), is reported to have antiandrogen activity in prostate carcinoma cells.[3]

Aplicación

2,2,5,7,8-Pentamethyl-6-chromanol is the suitable reagent used for the quantitative analysis of α-tocopherol by plasma-based gas chromatography/tandem mass spectrometry (GC/MS/MS) using a tabletop quadrupole ion trap mass spectrometer.[1] It may be employed as α-tocopherol model compound and on oxidation by t-butyl hydroperoxide in chloroform, in the presence of alcohol, affords 5-alkoxymethyl-2,2,7,8-tetramethyl-6-chromanol.[4] It may be used as internal standard for the determination of α- and γ-tocopherol in the rabbit serum and liver by HPLC.[5]

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves