285773

α-Estradiol

98%

• Sinónimos: 1,3,5(10)-Estratriene-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratriene, Epiestradiol
• Fórmula empírica (notación de Hill): C₁₈H₂₄O₂
• Número de CAS: 57-91-0
• Peso molecular: 272.38
• MDL number: MFCD00064144
• UNSPSC Code: 12352200
• PubChem Substance ID: 329753246

Propiedades

• assay: 98%
• impurities: <3% water
• SMILES string: [H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
• InChI key: VOXZDWNPVJITMN-SFFUCWETSA-N

Descripción

Biochem/physiol Actions

Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.