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11970

Sigma-Aldrich

1,3-Diphenyl-2-propenone

≥98.0% (GC)

Sinónimos:

Benzalacetophenone, Chalcone

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About This Item

Fórmula lineal:
C6H5CH=CHCOC6H5
Número de CAS:
94-41-7
Peso molecular:
208.26
Beilstein/REAXYS Number:
1210466
EC Number:
202-330-2
MDL number:
MFCD00003082
UNSPSC Code:
12352100
PubChem Substance ID:
57646947
NACRES:
NA.22

assay

≥98.0% (GC)

solubility

dioxane: soluble 1 g/10 mL, clear, colorless

SMILES string

O=C(\C=C\c1ccccc1)c2ccccc2

InChI

1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+

InChI key

DQFBYFPFKXHELB-VAWYXSNFSA-N

Gene Information

rat ... Ar(24208)

Application

1,3-Diphenyl-2-propenone was used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines.

Biochem/physiol Actions

1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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