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Merck

TRPV1

transient receptor potential cation channel, subfamily V, member 1

Sinónimos:
VR1
Especie:
ID UniProtKB:
ID del gen:
  • Human(7442) Summary: Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(193034) transient receptor potential cation channel, subfamily V, member 1
  • Rat(83810) transient receptor potential cation channel, subfamily V, member 1
  • domestic cat(101093406) transient receptor potential cation channel, subfamily V, member 1
  • chicken(395259) transient receptor potential cation channel, subfamily V, member 1
  • naked mole-rat(101720480) transient receptor potential cation channel, subfamily V, member 1
  • Domestic Rabbit(100008926) transient receptor potential cation channel, subfamily V, member 1
  • domestic cat(100303454) transient receptor potential cation channel, subfamily V, member 1
  • Zebrafish(561195) transient receptor potential cation channel, subfamily V, member 1
  • cow(539074) transient receptor potential cation channel, subfamily V, member 1
  • domestic guinea pig(100135466) transient receptor potential cation channel, subfamily V, member 1
  • Horse(100034158) transient receptor potential cation channel, subfamily V, member 1
  • sheep(101110158) transient receptor potential cation channel, subfamily V, member 1
  • dog(445457) transient receptor potential cation channel, subfamily V, member 1

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Small Molecule - Agonist

Referencia del producto
Descripción
Especie
Dihydrocapsaicin, from Capsicum sp., ≥85%,
Especie
rat, human
N-Oleoylethanolamine, ~98% (TLC),
Especie
human, mouse, rat

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
SB-366791, ≥98% (HPLC), powder,
Especie
human
6-Iodonordihydrocapsaicin, ≥98% (HPLC), solid,
Especie
human
Capsazepine, ≥98% (HPLC), solid,
Especie
human, rat
Capsaicin, ≥95%, from Capsicum sp.,
Especie
rat, human
Capsaicin, natural,
Especie
rat, human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-TRPV1 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunofluorescence
western blot
Anti-TRPV1 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
ELISA
western blot
Anti-TRPV1 Antibody, clone 1N19 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, monkey, mouse
Aplicación
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-Vanilloid Receptor-1 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reactividad de especies
rat
Aplicación
microarray
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
Olvanil, powder,
Especie
human
Capsaicin, ≥95%, from Capsicum sp.,
Especie
rat, human
Acetaminophen, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Capsaicin, natural,
Especie
rat, human
Acetaminophen, Pharmaceutical Secondary Standard; Certified Reference Material,
Especie
human

Small Molecule - Mixed Agonist/Antagonist

Referencia del producto
Descripción
Especie
Capsazepine, ≥98% (HPLC), solid,
Especie
human, rat

Small Molecule - Opener

Referencia del producto
Descripción
Especie
Capsaicin, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Capsaicin, Pharmaceutical Secondary Standard; Certified Reference Material,
Especie
human
Capsaicin, analytical standard,
Especie
human
Capsaicin, phyproof® Reference Substance,
Especie
human
Capsaicin, European Pharmacopoeia (EP) Reference Standard,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human TRPV1,
Especie
human
MISSION® esiRNA, targeting mouse Trpv1,
Especie
mouse