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Merck

PRKACB

protein kinase, cAMP-dependent, catalytic, beta

Sinónimos:
PKACB
Especie:
ID UniProtKB:
ID del gen:
  • Human(5567) Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2011]
  • Mouse(18749) protein kinase, cAMP dependent, catalytic, beta
  • Rat(293508) protein kinase, cAMP dependent, catalytic, beta
  • dog(479975) protein kinase, cAMP-dependent, catalytic, beta
  • chicken(424542) protein kinase, cAMP-dependent, catalytic, beta
  • naked mole-rat(101721558) protein kinase, cAMP-dependent, catalytic, beta
  • cow(282323) protein kinase, cAMP-dependent, catalytic, beta
  • domestic cat(101095353) protein kinase, cAMP-dependent, catalytic, beta
  • sheep(101108785) protein kinase, cAMP-dependent, catalytic, beta
  • Zebrafish(100538234) protein kinase, cAMP-dependent, catalytic, beta
  • domestic guinea pig(100712694) protein kinase, cAMP-dependent, catalytic, beta

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-PRKACB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
Hispidin, solid, ≥98% (HPLC),
Especie
human
GSK690693, ≥98% (HPLC),
Especie
human

Proteins

Referencia del producto
Descripción
Especie
Protein Kinase A Catalytic Subunit β, Active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human
PKAcβ, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human
Protein Kinase A from bovine heart, ≥0.8 units/μg protein, lyophilized powder,
Especie
cow

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human PRKACB,
Especie
human
MISSION® esiRNA, targeting mouse Prkacb,
Especie
mouse