KDM2A
lysine (K)-specific demethylase 2A
Sinónimos:
CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA
Especie:
Human KDM2A (22992), Mouse Kdm2a (225876), Rat Kdm2a (361700), Zebrafish kdm2a (799441), dog KDM2A (483702), chicken KDM2A (425999), cow KDM2A (540141), Horse KDM2A (100052955), domestic cat KDM2A (101090549), sheep KDM2A (101108003) ...Más
ID UniProtKB:
ID del gen:
- Human(22992) Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
- Mouse(225876) lysine (K)-specific demethylase 2A
- Rat(361700) lysine (K)-specific demethylase 2A
- Zebrafish(799441) lysine (K)-specific demethylase 2A
- dog(483702) lysine (K)-specific demethylase 2A
- chicken(425999) lysine (K)-specific demethylase 2A
- cow(540141) lysine (K)-specific demethylase 2A
- Horse(100052955) lysine (K)-specific demethylase 2A
- domestic cat(101090549) lysine (K)-specific demethylase 2A
- sheep(101108003) lysine (K)-specific demethylase 2A
- naked mole-rat(101713712) lysine (K)-specific demethylase 2A
- domestic guinea pig(100732285) lysine (K)-specific demethylase 2A
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Proteins
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Descripción
Especie
FBXL11 human, recombinant, expressed in baculovirus infected Sf9 cells, ≥15% (SDS-PAGE),
Especie
human