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Merck

GRIN1

glutamate receptor, ionotropic, N-methyl D-aspartate 1

Sinónimos:
GluN1, MRD8, NMDA1, NMDAR1, NR1
Especie:
ID UniProtKB:
ID del gen:
  • Human(2902) Summary: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
  • Mouse(14810) glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • Rat(24408) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • naked mole-rat(101720185) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • Horse(100059861) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • chicken(404296) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • sheep(443281) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • cow(100336579) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • domestic guinea pig(100301989) glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • dog(494007) glutamate receptor, ionotropic, N-methyl D-aspartate 1

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Small Molecule - Agonist

Referencia del producto
Descripción
Especie
D-Serine, ≥98% (TLC),
Especie
human
Spermine tetrahydrochloride, powder or crystals,
Especie
human
Taurine, ≥99%,
Especie
human, rat
D-Cycloserine, synthetic,
Especie
human
Dextromethorphan hydrobromide monohydrate, ≥99% (TLC),
Especie
human

Small Molecule - Allosteric Modulator

Referencia del producto
Descripción
Especie
Acamprosate calcium, ≥98% (HPLC), powder,
Especie
human
Acamprosate calcium, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 400.48 (C10H20CaN2O8S2),
Especie
human
Acamprosate calcium, British Pharmacopoeia (BP) Reference Standard,
Especie
human

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
CP-101,606, ≥98% (HPLC),
Especie
human
MDL 105,519, ≥98% (HPLC), solid,
Especie
rat, human
Ifenprodil (+)-tartrate salt, ,
Especie
human
Arcaine sulfate salt, ,
Especie
human
(±)-2-Amino-4-phosphonobutyric acid, solid,
Especie
rat, human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-NMDAR1 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence

immunohistochemistry

western blot
Monoclonal Anti-Glun1-Nr1 antibody produced in mouse, clone S308-48, purified immunoglobulin,
Reactividad de especies
human, mouse, rat
Aplicación
immunocytochemistry
immunohistochemistry

western blot
Anti-NMDAR1 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunohistochemistry

western blot
Anti-NMDAR1 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunohistochemistry

western blot
Anti-GRIN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry

Small Molecule - Blocker

Referencia del producto
Descripción
Especie
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Especie
human
Agmatine sulfate salt, ≥97%, powder,
Especie
human

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
Taurine, ≥99%,
Especie
human, rat
Pentamidine isethionate salt, powder,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human GRIN1,
Especie
human
MISSION® esiRNA, targeting mouse Grin1,
Especie
mouse