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Merck

FAS

Fas cell surface death receptor

Sinónimos:
ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Especie:
Human FAS (355), Mouse Fas (14102), Rat Fas (246097), fruit fly fas (36521), Zebrafish fas (768248), chicken FAS (395274), dog FAS (486469), domestic cat FAS (493881), Horse FAS (100071639), cow FAS (282488) ...Más
ID UniProtKB:
P25445, A9UJX4, B6VNV4, Q14292, Q14293, Q14294, Q14295, Q16652
ID del gen:
  • Human(355) Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
  • Mouse(14102) Fas (TNF receptor superfamily member 6)
  • Rat(246097) Fas cell surface death receptor
  • fruit fly(36521) faint sausage
  • Zebrafish(768248) Fas (TNF receptor superfamily, member 6)
  • chicken(395274) Fas (TNF receptor superfamily, member 6)
  • dog(486469) Fas (TNF receptor superfamily, member 6)
  • domestic cat(493881) Fas (TNF receptor superfamily, member 6)
  • Horse(100071639) Fas (TNF receptor superfamily, member 6)
  • cow(282488) Fas (TNF receptor superfamily, member 6)
  • sheep(100144426) Fas (TNF receptor superfamily, member 6)
  • Domestic Rabbit(100008609) Fas (TNF receptor superfamily, member 6)
  • domestic guinea pig(100726403) Fas cell surface death receptor
  • naked mole-rat(101704746) Fas cell surface death receptor

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ELISA

Referencia del producto
Descripción
Especie
RAB0177
Human Fas ELISA Kit, for cell and tissue lysates,
Especie
mouse
RAB0176
Human Fas ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Especie
mouse
RAB0784
Mouse Fas ELISA Kit, ,
Especie
mouse
RAB0893
Rat Fas / Tumor Necrosis Factor Receptor Superfamily Member 6 ELISA Kit, ,
Especie
rat

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
HPA027444
Anti-FAS antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
F4424
Monoclonal Anti-Fas, clone DX2, purified from hybridoma cell culture,
Reactividad de especies
human
Aplicación
flow cytometry
microarray
SAB4501532
Anti-FAS antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
ELISA
immunofluorescence
western blot
ZRB2342
Anti-Fas/CD95 Antibody, clone 1F17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, monkey
Aplicación
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
SAB5700278
Anti-Phospho-FAS-Y291 antibody produced in rabbit, ,
Reactividad de especies
human
Aplicación
western blot

Proteins

Referencia del producto
Descripción
Especie
F2053
Fas Intracellular Domain human, >90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution,
Especie
human
SRP6480
Fas/CD95 human, recombinant, expressed in HEK 293 cells, ≥92% (SDS-PAGE),
Especie
human
SRP3037
FAS Receptor human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Especie
human
F8799
Fas/Fc Chimera from mouse, >97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture,
Especie
mouse

esiRNA

Referencia del producto
Descripción
Especie
EHU060231
MISSION® esiRNA, targeting human FAS,
Especie
human
EMU031961
MISSION® esiRNA, targeting mouse Fas,
Especie
mouse