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59356-U

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Discovery® Cyano (5 µm) HPLC Columns

Discovery® Cyano HPLC Column

L × I.D. 15 cm × 4.6 mm, HPLC Column

Synonym(s):

Cyano Bonded Phase Column

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MXP 23,944.00

MXP 23,944.00

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1 EA
MXP 23,944.00

About This Item

UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52

MXP 23,944.00

In StockDetails

Product Name

Discovery® Cyano HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm

material

stainless steel column

Quality Level

100

Agency

suitable for USP L10

product line

Discovery®

feature

endcapped

manufacturer/tradename

Discovery®

packaging

1 ea of

extent of labeling

4.5% Carbon loading

parameter

≤70 °C temp. range
400 bar pressure (5801 psi)

technique(s)

HPLC: suitable
LC/MS: suitable

L × I.D.

15 cm × 4.6 mm

surface area

200 m2/g

surface coverage

3.5 μmol/m2

impurities

<10 ppm metals

matrix

silica gel, high purity, spherical base material
fully porous particle

matrix active group

cyano phase

particle size

5 μm

pore size

180 Å

operating pH range

2-8

application(s)

food and beverages

separation technique

hydrophilic interaction (HILIC)
normal phase
reversed phase

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General description

Discovery® Cyano HPLC column is used for the retention and separation of strongly basic analytes including quaternary ammonium salts, with excellent peak shapes.

Features and Benefits

  • Low hydrophobicity for rapid elution of hydrophobic analytes
  • Excellent peak shape and retention of strongly basic analytes
  • Retention of polar analytes
  • Unique selectivity
  • Significantly less retention than C18 (typically requires lower % organic mobile phase)
  • Stable, low-bleed LC-MS separations
  • Compatible with highly aqueous organic phases

Legal Information

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
293464-06
293464-05
293464-04
293464-03
293464-02

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Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
E F Nemeth et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at
Christophe Morisseau et al.
Analytical biochemistry, 414(1), 154-162 (2011-03-05)
The microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics. In addition, it has a potential role in sexual development and bile acid transport, and it is associated with a number of diseases such as
Srdan Verstovsek et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(3), 788-796 (2008-02-05)
The discovery of an activating somatic mutation in codon 617 of the gene encoding the Janus kinase (JAK)-2 (JAK2 V617F) in patients with myeloproliferative disorders has opened new avenues for the development of targeted therapies for these malignancies. However, no
K Umekawa et al.
Japanese journal of pharmacology, 84(1), 7-15 (2000-10-24)
We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung microsomes with an IC50 value of 42 nM and, at 10 - 100 microM, had no effect on other
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Questions

  1. Please provide the below details for the column Carbon loading%- Pore size- Surface area- pH stability- End capping-

    1 answer

    1. TS Answer:
      - 4.5% Carbon loading
      - Pore size: 180 Å
      - Surface area: 200 m2/g
      - Operating pH range: 2-8
      - Endcapped
      - Particle Size: 5 μm
      - Temperature Range: ≤70 °C
      - Maximum Pressure: 400 bar pressure (5801 psi)
      - Suitable for USP L10

      Helpful?

Reviews

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  1. India
    • Review 1
    • Votes 0
    2 out of 5 stars.

    Column to column variation

    Variation in Retention time from column to column observed

    Helpful?

    1. Response from MilliporeSigma:

      Thank you for your review. While minor variability between batches may occur, the degree of difference in retention times would be impacted by run times. Assuming all other conditions are identical, an overall +/- 5% may be possible. As there are a number of variables to consider, we encourage customers who experience problems with our products to call or email us for additional technical support. Please visit https://www.sigmaaldrich.com/US/en/support/customer-support to submit a Product Technical Inquiry.

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