SRP4576

BMP-11 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• Synonym(s): BMP 11, GDF11, Growth/Differentiation Factor-11, bone morphogenetic protein 11
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• Assay: ≥98% (HPLC); ≥98% (SDS-PAGE)
• form: lyophilized
• mol wt: ~32.6 kDa
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: endotoxin, tested
• NCBI accession no.: O95390
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... GDF11(10220)

Description

General description

BMPs (bone morphogenetic proteins) belong to the transforming growth factor-β (TGF-β) superfamily of structurally related signaling proteins. BMP-11 is also known as growth differentiation factor 11 (GDF11). Recombinant human BMP-11 is a N-terminus His-tagged protein with a molecular weight of 32.6kDa (for homodimeric) and 16.2kDa (for monomeric) consisting of 136 amino acid polypeptide chains.

Biochem/physiol Actions

As implied by their name, bone morphogenetic proteins (BMPs) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. They also enhance protein degradation and reduce skeletal muscle protein synthesis. BMP-11 may have a role in the development of the nervous system in mice. It acts as a modulator of development and differentiation. In mice, circulating levels of BMP-11 decrease with age.

Physical form

Lyophilized from 10 mM Sodium Citrate, pH 3.5.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 μg BSA per 1 μg of protein). This solution can then be diluted into other aqueous buffers.