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SML3777

Sigma-Aldrich

SAR7334

≥98% (HPLC)

Synonym(s):

SAR-7334, 4-({(1R,2R)-2-[(3R)-3-Aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)-3-chlorobenzonitrile, 4-[rac-trans-(1,2)-2-((R)-3-Aminopiperidin-1-yl)indan-1-yloxy]-3-chlorobenzonitrile, SAR 7334

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About This Item

Empirical Formula (Hill Notation):
C21H22ClN3O
CAS Number:
1333210-07-3
Molecular Weight:
367.87
MDL number:
MFCD27992059
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

TRPC6-selective transient receptor potential channel (TRPC) inhibitor.



SAR7334 is a TRPC6-selective transient receptor potential channel (TRPC) inhibitor (IC50 against OAG-induced Ca2+ influx in TRPC3/6/7-expressing cells = 9.5/226/282 nM, IC50 >10 μM in TRPC4/10 cells; IC50 = 7.9 nM by whole-cell patch-clamp using TRPC6-HEK-FITR cells).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels
British Journal of Pharmacology, 172(14), 3650-3660 (2015)
The role of TRPC6 calcium channels and P2 purinergic receptors in podocyte mechanical and metabolic sensing
Physiology international (2021)
TRPC6 inhibits renal tubular epithelial cell pyroptosis through regulating zinc influx and alleviates renal ischemia-reperfusion injury
Faseb Journal, 36(10) (2022)

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