SMB01077

Poliothyrsoside

≥85% (LC/MS-ELSD)

• Synonym(s): Nigracin
• Empirical Formula (Hill Notation): C₂₀H₂₂O₉
• CAS Number: 18463-25-7
• Molecular Weight: 406.38
• MDL number: MFCD20260826
• UNSPSC Code: 12352205
• NACRES: NA.25

Properties

• biological source: plant
• Assay: ≥85% (LC/MS-ELSD)
• form: solid
• mol wt: 406.38
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• SMILES string: O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1COC(=O)c3ccccc3)O)O)O)Oc2c(cc(cc2)O)CO
• InChI: 1S/C20H22O9/c21-9-12-8-13(22)6-7-14(12)28-20-18(25)17(24)16(23)15(29-20)10-27-19(26)11-4-2-1-3-5-11/h1-8,15-18,20-25H,9-10H2/t15-,16-,17+,18-,20-/m1/s1
• InChI key: FLROYCKIIJCTDY-BFMVXSJESA-N

Description

General description

Poliothyrsoside, also known as Nigracin, is a phenolic glycoside compound commonly found in plants such as Flacourtia indica, Loxocalyx urticifolius, Hydnocarpus annamensis, Xylosma flexuosa, Poliothyrsis sinensis, and Scolopia spinosa. Existing research suggests that this plant-derived metabolite exerts various biological activities, antioxidant, antidiabetic, anti-alzheimers and antiplasmodial properties.

Application

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical and biochemical research.

Biochem/physiol Actions

Poliothyrsoside is a pyruvic transaminase inhibitor known for its insulin-sensitizing effects in cell culture. Additionally, it exhibits anti-diabetic properties by inhibiting acetyl-CoA carboxylase, ultimately enhancing insulin sensitivity and lowering blood glucose levels in diabetic mice. This compound also serves as a lactate dehydrogenase inhibitor and demonstrates antidepressant-like actions, along with effectiveness against Alzheimer′s disease. In vitro studies have further revealed Poliothyrsoside′s capacity to inhibit virus production and exhibit antiviral activity against HIV-1.

Features and Benefits

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

Other Notes

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable