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SAB4503132

Sigma-Aldrich

Anti-FZD5 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

FZD5, Frizzled-5, Fz-5, FzE5, hFz5

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 64 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI accession no.

Q13467

UniProt accession no.

Q13467

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FZD5(7855)

General description

Anti-FZD5 Antibody detects endogenous levels of total FZD5 protein.
The FZD5 (frizzled class receptor 5) gene encodes a receptor FZ5 for Wnt proteins and is mapped to human chromosome 2q33.3.

Immunogen

The antiserum was produced against synthesized peptide derived from human FZD5.

Immunogen Range: 31-80

Biochem/physiol Actions

Fzd5 (frizzled class receptor 5) is a receptor component for the canonical and non-canonical Wnt signaling pathways which is necessary for cell proliferation and cell differentiation. Fzd5 might serve as an important biomarker for eye malformation. The Wnt5a-Fz5 complex is known to support the functions of innate immunity. Fzd5 along with Gcm1 (chorion-specific transcription factor) is involved in a feedback mechanism that regulates trophoblast differentiation and chorionic branching in placenta.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes
Meulenbelt I, et al.
European Journal of Human Genetics, 14(12), 1280-1280 (2006)
A Positive Feedback Loop Involving Gcm1 and Fzd5 Directs Chorionic Branching Morphogenesis in the Placenta
Lu J, et al.
PLoS Biology, 11(4), e1001536-e1001536 (2013)
Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ε and frizzled5.
Bernatik O, et al.
The Journal of Biological Chemistry, 289(34), 23520-23533 (2014)
A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma
Liu C, et al.
Human Molecular Genetics, 25(7), 1382-1391 (2016)
Wnt5a-Rac1-NF-κB homeostatic circuitry sustains innate immune functions in macrophages.
Naskar D, et al.
Journal of Immunology, 192(9), 4386-4397 (2014)
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