SAB4300830
Anti-UCN antibody produced in rabbit
affinity isolated antibody
Synonym(s):
UI, UROC
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100 μL
MXP 8,725.00
MXP 8,725.00
Estimated to ship onMay 01, 2025
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100 μL
MXP 8,725.00
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
MXP 8,725.00
Estimated to ship onMay 01, 2025
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
concentration
0.7 mg/mL
technique(s)
immunohistochemistry: 1:25- 1:100
isotype
IgG
accession no.
NP_003344.1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... UCN(7349)
General description
Urocortin (UCN) belongs to the hypothalamic hormone corticotrophin-releasing factor (CRF) family. UCN has 45% homology to CRF. UCN is expressed in brain, placenta, lymphocytes and heart. In human chromosome, the gene UCN is localized on 2p23.3.
Specificity
The antibody detects endogenous levels of total UCN protein.
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human urocortin
Application
Anti-UCN antibody produced in rabbit has been used in immunohistochemical analysis.
Biochem/physiol Actions
Urocortin (UCN1) is a key protein involved in regulating hypothalamic-pituitary-adrenal axis and modulating stress responses. Ucn1 is associated with both G-protein coupled CRF receptors and CRF binding proteins. UCN increases the heart rate, cardiac output, and coronary blood flow according to the dosage. UCN protects cardiac myocytes from cell death due to stress. Ucn upregulates p42/p44 mitogen activated protein kinase (MAPK) signalling pathway and protects the heart from reperfusion injury. High levels of Ucn mRNA have been observed in the Edinger−Westphal (EW) nucleus, associated with alcohol and drug addiction. Ucn delays the gastric emptying and reduces the food intake and thus regulates the body weight. Ucn enhances anxiogenic-like or stress-like effect. Ucn causes degranulation of mast cells and increases vascular permeability in response to stress. Ucn is found to be associated with stress induced atopic dermatitis or psoriasis.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Find documentation for the products that you have recently purchased in the Document Library.
A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
Koob GF and Heinrichs SC
Brain Research, 848(1-2), 141-152 (1999)
Urocortin protects the heart from reperfusion injury via upregulation of p42/p44 MAPK signaling pathway
Schulman D, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 52(4), H1481-H1488 (2002)
Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors
Singh LK, et al.
Journal of Pharmacology and Experimental Therapeutics, 288(3), 1349-1356 (1999)
W J Giardino et al.
Translational psychiatry, 7(1), e1021-e1021 (2017-02-01)
Midbrain neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) are activated by alcohol, and enriched with stress-responsive neuropeptide modulators (including the paralog of corticotropin-releasing factor, urocortin-1). Evidence suggests that EWcp neurons promote behavioral processes for alcohol-seeking and consumption, but a
Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway
Brar BK, et al.
The Journal of Biological Chemistry, 275(12), 8508-8514 (2000)
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