SAB4200706

Anti-TM4SF4 antibody, Mouse monoclonal

clone TM4SF-11, hybridoma cell culture supernatant

• Synonym(s): Anti-ILTMP, Anti-il-TMP transmembrane 4 L six family member 4
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: TM4SF-11, monoclonal
• form: buffered aqueous solution
• mol wt: antigen ~27 kDa
• species reactivity: rat, human, canine, monkey, mouse, bovine
• technique(s): immunoblotting: 1:4,000-1:8,000 using whole extract of HCT-116 cells
• isotype: IgM
• UniProt accession no.: P48230
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TM4SF4(7104) ; mouse ... Tm4sf4(229302) ; rat ... Tm4sf4(116467)

Description

General description

Anti-TM4SF4 antibody, Mouse monoclonal (mouse IgM isotype) is derived from the TM4SF-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with synthetic peptide from the internal region of human TM4SF4, conjugated to KLH. TM4SF4 (Transmembrane 4 L6 Family member 4) also known as ILTMP (intestine and liver tetraspan membrane protein) is a member of the transmembrane 4 superfamily (or tetraspanin family). It is a cell surface glycoprotein containing four transmembrane domains.

Immunogen

synthetic peptide from the internal region of human TM4SF4

Application

Anti-TM4SF4 antibody has been used in immunoblotting.

Biochem/physiol Actions

TM4SF4 (Transmembrane 4 L6 Family member 4) can intervene density-dependent cell proliferation. TM4SF4 levels increases in non-dividing epithelial cells during their differentiation and migration of intestinal crypts. TM4SF4 levels are upregulated in 80% of hepatocellular carcinoma (HCC) tissues and in stomach adenocarcinoma cells. Reduction of TM4SF4 expression in HCC cell lines by stably transfecting TM4SF4 antisense plasmid caused significant inhibition of cell proliferation.

Physical form

The product is supplied as a culture supernatant solution containing 15 mM sodium azide as a preservative. The product contains bovine serum albumin and a human-derived protein.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable