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SAB1406356

Sigma-Aldrich

Anti-PYCR1 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

P5C, P5CR, PIG45, PP222, PYCR

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~33.4 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: suitable
western blot: 1 μg/mL

NCBI accession no.

NM_006907.2

UniProt accession no.

P32322

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PYCR1(5831)

General description

Pyrroline-5-carboxylate reductase 1 (PYCR1) is a housekeeping gene.The gene is located on human chromosome 17q25.3.

Immunogen

PYCR1 (NP_008838.2, 1 a.a. ~ 319 a.a) full-length human protein.

Sequence
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD

Biochem/physiol Actions

Pyrroline-5-carboxylate reductase 1 (PYCR1) acts as a prognostic biomarker for breast cancer.Mutations in this gene affects mitochondrial function and is associated with connective tissue disorder cutis laxa.It helps in cell metabolism.This protein catalyses the conversion of 1-piperideine-6-carboxylate (P6C) into pipecolic acid.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers
Ding, Ji , et al.
Carcinogenesis, 38(5), 519-531 (2017)
Human pyrroline-5-carboxylate reductase (PYCR1) acts on Delta 1-piperideine-6-carboxylate generating L-pipecolic acid
Struys,, et al.
Journal of inherited metabolic disease, 37(3), 327-332 (2014)
Improving the prediction accuracy in classification using the combined data sets by ranks of gene expressions
Kim, Ki, et al.
BMC Bioinformatics, 9(1), 283-283 (2008)
Resolving the cofactor binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1
Christen, et al.
Test, jbc-M117 (2017)
Knockdown of PYCR1 inhibits cell proliferation and colony formation via cell cycle arrest and apoptosis in prostate cancer
Zeng, Te, et al.
Medical Oncology (Northwood, London, England), 34(2), 27-27 (2017)

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