SAB1300736

Anti-Phospho-ANTXR1-pY425 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-ANTXR1, Anti-ATR, Anti-Anthrax toxin receptor 1, Anti-TEM8, Anti-Tumor endothelial marker 8
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): dot blot: suitable; indirect ELISA: 1:1000
• NCBI accession no.: NP_115584
• UniProt accession no.: Q9H6X2
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr425)
• Gene Information: human ... ANTXR1(84168)

Description

General description

ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.

Immunogen

ANTXR1 (NP_115584, 409-442)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y425 of human ANTXR1.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable