Pcp2 may function as a cell-type specific modulator for G protein-mediated cell signaling. PCP2 (Purkinje cell protein 2) codes for a protein belonging to the GoLoco domain-containing family. Pcp2 is specifically localized to cerebellum in the Purkinje cells and in retinal bipolar cells. From Pcp2 protein structural analysis, it is known that Pcp2 contains two GoLoco motifs.
Immunogen
PCP2 (NP_032816, ) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of mouse Pcp2.
Biochem/physiol Actions
Pcp2 might serve as an inhibitor of guanine nucleotide dissociation.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2).
Willard F S, et al.
Cellular Signalling, 18(8), 1226-1234 (2006)
Retinal ON bipolar cells express a new PCP2 splice variant that accelerates the light response.
Xu Y, et al.
The Journal of Neuroscience, 28(36), 8873-8884 (2008)
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
