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SAB1104559

Sigma-Aldrich

Anti-NUPR1 (47-60) antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-COM1, Anti-Nuclear protein, transcriptional regulator, 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen predicted mol wt ~9 kDa

species reactivity

human

technique(s)

western blot: 1:500-1:2,000

UniProt accession no.

O60356

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NUPR1(26471)

General description

The NUPR1 (nuclear protein 1, transcriptional regulator) gene is mapped to human chromosome 16p11.2 and encodes a chromatin remodeling protein of 8.8 KDa.

Immunogen

synthetic peptide corresponding to amino acids 47-60 of human NUPR1

Application

Anti-NUPR1 (47-60) antibody produced in rabbit has been used in western blot analysis.

Biochem/physiol Actions

Nupr1 (nuclear protein 1, transcriptional regulator) is a stress response factor, induced by lipopolysaccharides, CCl4, starvation, cell cycle arrest and other protein stimuli. NUPR1 is associated with tumor cell proliferation, metastasis and apoptosis, also regulates entosis, matrix remodeling and autophagy. It serves as a substrate for protein kinase A. Overexpression of this gene is observed in glioblastoma and hepatocellular carcinoma. The protein function is tissue specific and differs at molecular level. It can act as a tumor suppressor or inducer.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.
Maida A, et al.
The Journal of Clinical Investigation, 126(9), 3263-3278 (2016)
Pivotal role of the chromatin protein Nupr1 in Kras-induced senescence and transformation.
Grasso D, et al.
Scientific Reports, 5, 17549-17549 (2015)
Priscila R Andrade et al.
PLoS neglected tropical diseases, 13(7), e0007589-e0007589 (2019-07-26)
The initial interaction between a microbial pathogen and the host immune response influences the outcome of the battle between the host and the foreign invader. Leprosy, caused by the obligate intracellular pathogen Mycobacterium leprae, provides a model to study relevant
Knockdown of NUPR1 inhibits the proliferation of glioblastoma cells via ERK1/2, p38 MAPK and caspase-3.
Li J, et al.
Journal of Neuro-Oncology, 132(1), 15-26 (2017)
A new microRNA signal pathway regulated by long noncoding RNA TGFB2-OT1 in autophagy and inflammation of vascular endothelial cells.
Huang S, et al.
Autophagy, 11(12), 2172-2183 (2015)
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