Retinol Binding Protein is a transport protein of Vitamin A. There are a number of publications available regarding the biological activtity and functionality of this protein. See the link below to access a review article that may be of interest:
https://www.frontiersin.org/articles/10.3389/fphys.2021.659977/full
R9388
Retinol Binding Protein from human urine
buffered aqueous solution
Synonym(s):
CRBP, Cellular retinol binding protein, RBP, RBP-1, Retinol Binding Protein I
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0.5 MG
MXP 6,582.00
About This Item
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biological source
human urine
Quality Level
Assay
≥85% (SDS-GE)
form
buffered aqueous solution
technique(s)
cell culture | embryo: suitable
transfection: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... RBP1(5947)
General description
Retinol Binding Protein (RBP) is a member of lipocalin superfamily.[1] The normal concentration of RBP in serum is 40 to 50 μg/mL and has a molecular weight of 21 kDa. It has a turnover rate of 4 to 24 h.[2] RBP is produced in the liver in response to retinol binding trigger. It is also produced in kidney, sertoli cells of testis.[1] RBP contains a single globular domain and a highly conserved N-terminal region. It has eight antiparallel β sheets in the centre which binds retinol.[3] In human chromosome, the gene encoding RBP is localised at 3q23.[4]
Application
Retinol Binding Protein from human urine has been used:
- as one of the protein in microinjecting mesencephalic cavity of chicken eggs to monitor embryonic cerebrospinal fluid/embryonic serum protein transfer[5]
- as an additive in basal medium for RNA transfection experiments[6]
- in the antibody-derivatized affinity pipettes preparation for the capture of affinity proteins[7]
Biochem/physiol Actions
Inflammation induced by lipopolysaccharide (LPS) exposure caused a reduction in the level of retinol binding protein produced by the liver. [8]
Retinol Binding Protein (RBP) is a specific protein for the transport of vitamin A. The apo-RBP, formed after delivering retinol to the tissues is catabolized by the kidney. The plasma concentration of RBP is less in diabetes mellitus patients.[2] RBP binds to the carrier protein transerythrin, to prevent its loss during glomerular filtration.[1] RBP is implicated in initial neurogenesis and neuroepithelial cell proliferation.[5] RBP is responsible for blepharophimosis syndrome (BPES).[4]
Physical form
Solution in 10 mM sodium phosphate, pH 7.4, 150 mM NaCl, and 0.05% NaN3
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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F J Rosales et al.
Journal of lipid research, 37(5), 962-971 (1996-05-01)
The acute inflammatory response to tissue injury and infection is associated with low concentrations of plasma retinol and its specific transport proteins, retinol-binding protein (RBP) and transthyretin (TTR). To examine the kinetics and mechanism of hyporetinemia, we have induced acute
Vitamin A in Health and Disease, 87-95 (1994)
Laboratory Tests for the Assessment of Nutritional Status, Second Edition (1999)
Plasma retinol binding protein: structure and function of the prototypic lipocalin
Newcomer ME and Ong DE
Biochimica et Biophysica Acta, Protein Structure and Molecular Enzymology, 1482(1-2), 57-64 (2000)
Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta' subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization
De Baere E, et al.
Cytogenetics and Cell Genetics, 82, 226-227 (1998)
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