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PZ0412

Sigma-Aldrich

PF-06427878

≥98% (HPLC)

Synonym(s):

(R)-3-((2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxamido)methyl)benzoic acid, 3-[[[[2-[(3R)-3-(2-Ethoxyphenoxy)-1-piperidinyl]-5-pyrimidinyl]carbonyl]amino]methylbenzoic acid, PF 06427878, PF06427878

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5 MG
MXP 2,293.00
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MXP 9,258.00

MXP 2,293.00

Estimated to ship onMarch 23, 2025

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5 MG
MXP 2,293.00
25 MG
MXP 9,258.00

About This Item

Empirical Formula (Hill Notation):
C26H28N4O5
CAS Number:
1809064-23-0
Molecular Weight:
476.52
UNSPSC Code:
51111800
NACRES:
NA.77

MXP 2,293.00

Estimated to ship onMarch 23, 2025

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

O=C(C1=CC=CC(CNC(C2=CN=C(N=C2)N3C[C@@H](CCC3)OC4=CC=CC=C4OCC)=O)=C1)O

InChI

1S/C26H28N4O5/c1-2-34-22-10-3-4-11-23(22)35-21-9-6-12-30(17-21)26-28-15-20(16-29-26)24(31)27-14-18-7-5-8-19(13-18)25(32)33/h3-5,7-8,10-11,13,15-16,21H,2,6,9,12,14,17H2,1H3,(H,27,31)(H,32,33)/t21-/m1/s1

InChI key

IDVOZBCJUVAIMF-OAQYLSRUSA-N

Biochem/physiol Actions

PF-06427878 is an orally active, potent and selective diacylglycerol acyltransferase 2 inhibitor (human/rat DGAT2 IC50 = 99/202 nM; >470-fold selectivity over DGAT1, MGAT1/2/3) that inhibits DGAT2-dependent triglyceride (TG) synthesis in primary human hepatocytes (IC50 = 11.6 nM in the presence of DGAT1 inhibitor PF-04620110). PF-06427878 reduces hepatic and circulating plasma TG levels as well as lipogenic gene expression in rats maintained on a Western-type diet (0.3-30 mg/kg bid. po.). Likewise, PF-06427878 significantly improves steatosis and hepatocellular ballooning with a decrease in lobular inflammation in a murine nonalcoholic steatohepatitis (NASH) model (2 or 20 mg/kg bid. po.).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Neeta B Amin et al.
Science translational medicine, 11(520) (2019-11-30)
Nonalcoholic steatohepatitis (NASH) is characterized by the accumulation of hepatocyte triglycerides, the synthesis of which is catalyzed by diacylglycerol acyltransferases (DGATs). Here, we investigate DGAT2 as a potential therapeutic target using an orally administered, selective DGAT2 inhibitor, PF-06427878. Treatment with

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