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P9768

Sigma-Aldrich

Phorbol 12,13,20-triacetate

powder

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About This Item

Empirical Formula (Hill Notation):
C26H34O9
CAS Number:
19891-05-5
Molecular Weight:
490.54
MDL number:
MFCD00056371
UNSPSC Code:
12352202
PubChem Substance ID:
24899062

form

powder

color

white

storage temp.

−20°C

SMILES string

CC1C(OC(C)=O)C2(OC(C)=O)C(C3C=C(COC(C)=O)CC4(O)C(C=C(C)C4=O)C13O)C2(C)C

InChI

1S/C26H34O9/c1-12-8-19-24(31,21(12)30)10-17(11-33-14(3)27)9-18-20-23(6,7)26(20,35-16(5)29)22(34-15(4)28)13(2)25(18,19)32/h8-9,13,18-20,22,31-32H,10-11H2,1-7H3/t13-,18+,19-,20-,22-,24-,25-,26-/m1/s1

InChI key

LASMKIAVFGUYEG-SEYWVDNQSA-N

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
115H0629

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C K Too et al.
Endocrinology, 121(4), 1503-1511 (1987-10-01)
Stimulation of mitogenesis in rat Nb2 node lymphoma cells by human (h) PRL was inhibited by inhibitors of Na+/H+ exchange (viz. amiloride and its analogs) and inhibitors of protein kinases (isoquinolinesulfonamide derivatives). The most potent were ethylisopropylamiloride (EP-Am) (IC50, 13
K R Stratton et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(7), 2498-2501 (1989-04-01)
We have used the hippocampal slice preparation to investigate the regulation of protein tyrosine phosphorylation in brain. After pharmacological treatment of intact slices, proteins were separated by electrophoresis, and levels of protein tyrosine phosphorylation were assessed by immunoblotting with specific
Gary Glenn et al.
FEBS letters, 581(28), 5377-5381 (2007-10-31)
The CSF-1 receptor is a protein-tyrosine kinase that has been shown to undergo regulated intramembrane proteolysis, or RIPping. Here, we have compared receptor downregulation and RIPping in response to CSF-1 and TPA. Our studies show that CSF-1 is a relatively

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