P6001

p-Phenylenediamine

98% (GC)

• Synonym(s): 1,4-Benzenediamine, 1,4-Diaminobenzene, 1,4-Phenylenediamine
• Linear Formula: C₆H₄(NH₂)₂
• CAS Number: 106-50-3
• Molecular Weight: 108.14
• Beilstein: 742029
• EC Number: 203-404-7
• MDL number: MFCD00007901
• UNSPSC Code: 12352204
• PubChem Substance ID: 24898724
• NACRES: NA.83

Properties

• vapor density: 3.7 (vs air)
• vapor pressure: 1.08 mmHg ( 100 °C)
• description: anti-fade reagent
• Assay: 98% (GC)
• bp: 267 °C (lit.)
• mp: 138-143 °C (lit.)
• SMILES string: Nc1ccc(N)cc1
• InChI: 1S/C6H8N2/c7-5-1-2-6(8)4-3-5/h1-4H,7-8H2
• InChI key: CBCKQZAAMUWICA-UHFFFAOYSA-N

Description

Application

p-Phenylenediamine has been used:

• to evaluate its sensitization potential in vitro in langerhans-like dendritic cells and autologous T cells
• to treat the dorsal sides of the ears of mice, to study its systemic immunological effects
• in glycerol to coverslip coronal sections in the attempt to count Aβ plaques

Anti-fade reagent is added to the mounting medium in fluorescence microscopy to retard photobleaching of fluorescein and other fluorescent dyes.

Biochem/physiol Actions

p-Phenylenediamine causes allergic reactions with skin. It is widely used in hair dyes. It eventually forms Bandrowski′s base, which is found to be the primary cause for allergy. p-Phenylenediamine exposure results in dermatitis, urticaria and anaphylaxis. It acts as an electron donor and is known to reduce cytochrome c.

Caution

Darkens in storage.

Safety Information

• Pictograms: GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H301 + H311 + H331,H317,H319,H370,H410
• Precautionary Statements: P273 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 1 Oral
• Target Organs: Kidney,Heart,Musculo-skeletal system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): 230.0 °F - closed cup
• Flash Point(C): 110 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves