![Poly[d(I-C)] lyophilized, pkg of 10 U (10108812001 [A<sub>260</sub> units]), pkg of 50 U (11219847001 [A<sub>260</sub> units])](/deepweb/assets/sigmaaldrich/product/images/352/091/ef743cea-ccd8-44f1-8f3b-dec5a1e4f5d1/640/ef743cea-ccd8-44f1-8f3b-dec5a1e4f5d1.jpg)
This product is soluble in water or neutral buffer. Solubility is no longer considered part of the specifications, but it was previously reported to be soluble at 20 mg/mL in 0.1 M Tris-HCl, pH 8.8. Heat is not necessary to solubilize the product; dissolving in an appropriate solvent is the recommended method for resuspension.
P4929
Poly(deoxyinosinic-deoxycytidylic) acid sodium salt
double-stranded alternating copolymer
Synonym(s):
Poly(dI-dC) • Poly(dI-dC) sodium salt
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5 UNITS
MXP 4,778.00
10 UNITS
MXP 7,639.00
25 UNITS
MXP 15,264.00
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5 UNITS
MXP 4,778.00
10 UNITS
MXP 7,639.00
25 UNITS
MXP 15,264.00
About This Item
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Application
Poly(deoxyinosinic-deoxycytidylic) acid (Poly(dI-dC) • Poly(dI-dC)) is an alternating copolymer used as a DNA substrate for evaluation of DNA methytransfeases, such as DNA-methyltransferase 1 and as double-stranded DNA model for conformational studies of DNA structure dynamics and drug, small molecule, interactions.
Poly(deoxyinosinic-deoxycytidylic) acid sodium salt has been used in a study that synthesized and characterized bis(2-(pyrimidin-2-γl)ethoxy)alkanes and their pharmacological activity. Poly(deoxyinosinic-deoxycytidylic) acid sodium salt has also been used in a study that investigated the growth of calcium carbonate films on LB/LbL matrices.
Poly(deoxyinosinic-deoxycytidylic) acid sodium salt has been used in the electrophoretic mobility shift assay in p65 protein[1] and neuro-2A protein lysate.[2] It has also been used as a substrate in the protein arginine methyltransferase 1 (PRMT1) and DNA methyltransferase 1 (DNMT1) selectivity assay.[3]
Biochem/physiol Actions
Other Notes
Double-stranded alternating copolymer
Unit Definition
One unit will yield an A260 of 1.0 in 1.0 ml of 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1 cm light path)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Should I heat the product P4929-25U after resuspension to make aliquots? If yes, then how long and at what temperature? Thank you!
1 answer-
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What is the molecular weight of Product P4929, Poly(deoxyinosinic-deoxycytidylic) acid sodium salt?
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Molecular weight: Polymer size (by agarose gel electrophoresis) is lot dependent with a lower range of less than 150 to 550 base pairs and a high range of 3000 to over 5000 base pairs. Most of the material is between 1200 to 3000 base pairs.
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What is the solubility of Is Product P4929, Poly(deoxyinosinic-deoxycytidylic) acid sodium salt (Poly(dI-dC)?
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This product is soluble in water or neutral buffer at 20 mg/ml.
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How many milligrams of Product P4929, Poly(deoxyinosinic-deoxycytidylic) acid sodium salt, do I have?
1 answer-
The specifications for the product is approximately 13 U/mg, but the exact amount is lot specific. One unit will yield an A260 of 1.0 in 1.0ml of water. For example, the 5 unit size has approximately 0.384 mg.
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Is Is Product P4929, Poly(deoxyinosinic-deoxycytidylic) acid sodium salt (Poly(dI-dC), stable in solution?
1 answer-
Both the solution and solid are very stable and can be stored for extended periods (years) at -20 °C.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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