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P3150

Sigma-Aldrich

Poly(Lys, Phe) 1:1 hydrobromide

mol wt 20,000-50,000

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About This Item

CAS Number:
26700-39-0
MDL number:
MFCD00166387
UNSPSC Code:
12352209
NACRES:
NA.26
Pricing and availability is not currently available.

form

powder

Quality Level

200

feed ratio

Lys:Phe (1:1)

mol wt

20,000-50,000

color

white to off-white

application(s)

cell analysis

storage temp.

−20°C

Application

Poly (Lys, Phe) 1:1 hydrobromide has been used as a surfactant to bind negatively charged plasmid DNA. It has also been used to study its interaction with solvatochromic fluorescent dyes.[1][2]

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000362238
0000362240
0000362239
0000362240
0000362239

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Synthesis and properties of alternating poly(Lys-Phe) and comparison with the random copolymer poly(Lys 51, Phe 49).
G Seipke et al.
Biopolymers, 13(8), 1621-1633 (1974-01-01)
An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation
Emma V. Yates
The Journal of Physical Chemistry, 120 (9), 2087?2094-2087?2094 (2016)
Optimising DNA binding to carbon nanotubes by non-covalent methods
Vanesa Sanz
Carbon, 49(5), 1775-1781 (2011)
Helen Sjögren et al.
Biophysical chemistry, 116(1), 11-21 (2005-05-25)
The transition from alpha-helix to random coil of the titrating polyamino acid co-poly-L-(lysine, phenylalanine), (p-(Lys,Phe)), has been investigated as a function of pH and ionic strength in aqueous solution and at the air-water interface by means of circular dichroism (CD)
Tae Woo Kim et al.
International journal of pharmaceutics, 295(1-2), 35-45 (2005-04-26)
To enhance the in vitro and in vivo transfection activity of the cationic lipid emulsion (LE), three natural polycations, protamine sulfate (PS), poly-L-lysine and spermine, were selected as DNA condensing active agents. Formation of the LE/polycation/DNA ternary complexes was identified

Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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