O2501
Ornithine Transcarbamylase from Streptococcus faecalis
lyophilized powder, ≥300 units/mg protein
Synonym(s):
Carbamoylphosphate:L-Ornithine Carbamoyltransferase, OTCase, Ornithine Carbamoyl Transferase
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About This Item
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form
lyophilized powder
Quality Level
specific activity
≥300 units/mg protein
composition
Protein, ≥65% Lowry
storage temp.
−20°C
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Biochem/physiol Actions
Mutations in ornithine transcarbamylase cause Ornithine transcarbamylase deficiency which prevents the clearance of the byproduct ammonia leading to hyperammonemia. [1]
Unit Definition
One unit will form 1.0 μmole of citrulline from ornithine and carbamyl phosphate per min at pH 8.5 at 37 °C.
Physical form
Lyophilized powder contains Tris buffer salts
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Tatjana Skrbić et al.
PLoS computational biology, 8(6), e1002504-e1002504 (2012-06-22)
Stochastic simulations of coarse-grained protein models are used to investigate the propensity to form knots in early stages of protein folding. The study is carried out comparatively for two homologous carbamoyltransferases, a natively-knotted N-acetylornithine carbamoyltransferase (AOTCase) and an unknotted ornithine
Gabriela Jenikova et al.
Vaccine, 29(51), 9529-9537 (2011-10-18)
Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide, yet preventive medical strategies are not available. A crude veterinary vaccine has been licensed for cats and dogs, but no defined human vaccine is available. We tested the vaccine
James M Wilson et al.
Molecular genetics and metabolism, 105(2), 263-265 (2011-12-02)
A 66 year old woman who is a manifesting heterozygote for ornithine transcarbamylase deficiency (OTCD) presented with hepatocellular carcinoma (HCC). Fourteen years prior to this presentation she participated in a phase I gene therapy study which used an adenoviral vector
Luis Mariano Polo et al.
PloS one, 7(2), e31528-e31528 (2012-03-01)
Transcarbamylases reversibly transfer a carbamyl group from carbamylphosphate (CP) to an amine. Although aspartate transcarbamylase and ornithine transcarbamylase (OTC) are well characterized, little was known about putrescine transcarbamylase (PTC), the enzyme that generates CP for ATP production in the fermentative
Taiichi Wakiya et al.
Molecular genetics and metabolism, 105(3), 404-407 (2012-01-24)
There are no objective and concrete guidelines for the management of Ornithine transcarbamylase deficiency (OTCD). Based on previous findings, we hypothesized that patients with OTCD have a low Ornithine transcarbamylase (OTC) activity in the liver, and therefore it would be
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