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N7904

Sigma-Aldrich

NS 521 oxalate

solid

Synonym(s):

1-(1-Butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine oxalate, 1-(1-Butyl-piperidin-4-yl)-1,3-dihydro-benzimidazol-2-one-oxalate

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About This Item

Empirical Formula (Hill Notation):
C16H23N3O · C2H2O4
CAS Number:
Molecular Weight:
363.41
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

form

solid

color

white

solubility

H2O: 10 mg/mL

SMILES string

OC(=O)C(O)=O.CCCCN1CCC(CC1)N2C(=O)Nc3ccccc23

Biochem/physiol Actions

Novel benzimidazolone neuroprotective agent.

Legal Information

Sold under license from NeuroSearch (US Patent #6, 180,649).

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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M Grønborg et al.
The Journal of pharmacology and experimental therapeutics, 290(1), 348-353 (1999-06-25)
NS521 (1-(1-butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine) belongs to a group of novel benzimidazolones, which exhibit neurotrophic-like activities. In vitro, NS521 rescued neuronal PC12 cells from death induced by serum and nerve growth factor deprivation. The survival effect of NS521 appeared to reflect a delay

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