M4154
β-N-Methylamino-L-alanine hydrochloride
Synonym(s):
L-BMAA
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About This Item
Empirical Formula (Hill Notation):
C4H10N2O2 · HCl
CAS Number:
Molecular Weight:
154.60
MDL number:
UNSPSC Code:
12352200
Recommended Products
storage temp.
2-8°C
SMILES string
CNCC(N)C(O)=O
Biochem/physiol Actions
Neuroexcitotoxic amino acid; may be involved in Guam amyotrophic lateral sclerosis
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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András Guseo
Orvosi hetilap, 153(52), 2060-2069 (2012-12-25)
Parkinson's disease is one of the most frequent progressive degenerative disorders with unknown origin of the nervous system. The commutation of the disease on Guam led to the discovery of a neurotoxin which was also found in other continents. This
Elijah W Stommel et al.
Medical hypotheses, 80(2), 142-145 (2012-12-19)
Sporadic amyotrophic lateral sclerosis (sALS) is a fatal neurodegenerative disease with no known cause. There are many clues to suggest an environmental trigger for the disease, including reports of conjugal couples and co-localized employees that developed sALS. On the island
Travis Rush et al.
Neuroreport, 23(4), 216-219 (2012-02-09)
Determination of the environmental factors involved in neurodegenerative diseases has been elusive. Methylmercury and β-N-methylamino-L-alanine (BMAA) have both been implicated in this role. Exposure of primary cortical cultures to these compounds independently induced concentration-dependent neurotoxicity. Importantly, concentrations of BMAA (10-100
Liying Jiang et al.
Analytical and bioanalytical chemistry, 405(4), 1283-1292 (2012-11-28)
The cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) is an amino acid that is putatively associated with the pathology of amyotrophic lateral sclerosis/Parkinsonism-dementia complex (ALS-PDC) disease. It raises serious health risk concerns since cyanobacteria are ubiquitous thus making human exposure almost inevitable. The
Steven A Cohen
The Analyst, 137(9), 1991-2005 (2012-03-17)
The non-protein amino acid L-α-amino-β-methylaminopropionic acid (BMAA) has been linked to several neurodegenerative diseases. Its presence in trace amounts in complex sample such as bacterial, plant and mammalian tissue extracts and hydrolyzates makes analysis a complicated process requiring good analytical
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